Clostridium welchii, enzymes, effect

Clostridium welchii, enzymes, effect on blood group substances, IV, 55 Coacervation, I, 277 Coatings, cellulose ester, I, 323 Co-carboxylase, II, 124 Coccidioides immitis, polysaccharide formed by, II, 225 Cocositol, III, 60 Coir, xylan peroentage in, V, 271 Collagenaae, effect on blood group substances, IV, 55... 

Putrefactive hacteria, such as Clostridium welchii, which frequently invade human blood during the agonal period or immediately after death, produce the enzyme neuraminidase ( 9). Neuraminidase has been shown to effect the heterogeneity of electrophoretic banding patterns of the human prostate acid phosphatase (10). The effect of this enzyme on EAP is not known. 

Histidine decarboxylase from E. coli has a pH optimum near 4.0, while a similar enzyme assayed in Clostridium welchii has a pH optimum near 2.5. Extracts of acetone- or dioxane-treated C. welchii, however, have maximal rates of histidine decarboxylation at pH 4.5. The reason for the difference in pH optima of intact cells and extracts is conventionally attributed to pH effects on cell permeability, but other factors may be responsible. It is noteworthy in this connection that the Km of histidine is the same for both types of preparation. For years no cofactor could be found for this enzyme, but recently it was found that both pyridoxal phosphate and Fe+++ or Al are required. ... 

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