Clopidogrel interactions

Lindvall G, Sartipy U, Bjessmo S, Svenarud P, Lindvall B, van der Linden J. Aprotinin reduces the antiplatelet effect of clopidogrel. Interact Cardiovasc Thorac Surg 2009 9(2) 178-81. 

Drug interactions Caution is called for when administering tenecteplase with drugs that affect platelet function such as aspirin, dipyridamole, clopidogrel, and glycoprotein Ilb/IIIa inhibitors. Administration of tenecteplase before, during, or after any of these drugs may increase the risk of... 

Lau WC. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation a new drug-drug interaction. Circulation 2003 107 32-7. 

Saw J. Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial. Circulation 2003 108 921 1. 

Serebruany VL, Midei MG, Malinin AI, Oshrine BR, Lowry DR, Sane DC, Tanguay JF, Steinhubl SR, Berger PB, O Connor CM, Hennekens CH. Absence of interaction between atorvastatin or other statins and clopidogrel results from the interaction study. Arch Intern Med 2004 164(18) 2051-7. 

P2Y12 receptor is required for complete aggregation response to ADR Nevertheless, both (Fig. 6) receptors interact to lead the full response. ADP potentiates platelet secretion and irreversible aggregation, Enzymatic conversion of released ADP to inactive AMP by endothelial ecto-ADPase limits platelet activation by ADR Thienopyridines (ticlopidine, clopidogrel, prasugrel, cangrelor) are used for inhibiting ADP-induced platelet function in the prevention of acute coronary events,... 

Lau WC, Carville DG, Bates ER. Clinical significance of the atorvastatin-clopidogrel drug-drug interaction. Circulation 2004 I I0 e66-e67 author reply e66-e67. 

Cilostazol is a PDE3 inhibitor and also is a drug with multiple mechanisms of action (23,24), some of which are directly platelet-related, and others of which exert their effects indirectly via endothelial cells (Figs, 4 and 5), As a PDE inhibitor, it increases the concentration of cyclic nucleotides within platelets and inhibits platelet aggregation in response to shear forces (via ADP) and a variety of agonists. Like other inhibitors of platelet activation, it blocks the expression and release of P-selectin, a key adhesion molecule on the membrane of platelet alpha granules that externalizes with activation, and plays an important role in the interactions between platelets, endothelial cells, and leukocytes, The effect of cilostazol on P-selectin expression appears to be additive to those of aspirin and clopidogrel (25). 

Xiao Z, Theroux R Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome. J Am Coll Cardiol 2004 43 1 982-1988. 

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