Clopidogrel clinical relevance

Would clopidogrel in addition to aspirin (intervention) prevent death or coronary events (clinically relevant outcome) in this patient with unstable angina (patient with a problem) who is currently on aspirin alone (comparison intervention) ... 

Clopidogrel does not appear to have a clinically relevant effect on the pharmacokinetics or pharmacodynamics of warfarin. Nevertheless, concurrent use might increase the bleeding risk. 

There is an increased risk of bleeding if clopidogrel is given with aspirin, but the use of low-dose aspirin and clopidogrel can be beneficial. Ticlopidine increases the antia r ant effects of aspirin and there is an increased risk of bleeding on concurrent use. Cilostazol appears not to interact to a clinically relevant extent with low-dose aspirin, and the addition of dipyridamole to aspirin does not appear to increase the incidence of bleeding. 

Mohammad A, Brilakis ES, Weideman RA, Little BB, Baneijee S. The clinical relevance of the Clopidogrel-Protonpump inhibitor interaction. J Cardiovasc Transl Res 2012 5(4) 547-52. 

Labarthe B, Theroux R Angioi M, Ghitescu M. Matching the evaluation of the clinical efficacy of clopidogrel to platelet function tests relevant to the biological properties of the drug. J Am Coll Cardiol 2005 46 638-645,... 

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