Clomethiazole edisilate

Clomethiazole edisilate/ Heminevrin Capsules/ AstraZeneca / sedative... 

Clomethiazole edisilate/Heminevrin Capsules/ AstraZeneca/2002 H3C Sedative 1-4 capsules as needed Soft gelatin capsule 192 mg Medium-chain triglycerides from fractionated coconut oil RT... 

Ten female patients aged 66 to 90 years were given clomethiazole edisilate syrup SOO mg each evening and 250 mg each morning as a sedative, with furosemide 20 to 80 mg. No significant changes in the serum levels or effects of clomethiazole or furosemide were detected, and no other significant adverse reactions were seen. ... 

Medium-chain triglycerides solubilize 192 mg of clomethizole edisilate in Heminevrin Capsules soft gelatin capsules (60 mg equivalent of clomethiazole). Clomethiazole is an oily viscous liquid as the free base but the edisilate (ethanedisulfonate) salt is a solid. Clomethiazole is a short-acting hypnotic and sedative with anticonvulsant effects, and Heminevrin is indicated for treatment of resdessness and insomnia that accompany alcohol withdrawal. Clomethiazole has a short half-life and low bioavailability due to extensive hepatic hrst-pass metabolism. The dose of Heminevrin is one to four capsules as needed, and the capsules are stored at room temperature. Heminevrin Capsules have been available in the United Kingdom since 1998. 

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