Clinical significance minimally clinically relevant difference

Cortisol and aldosterone concentrations were reduced by etomidate in adults (403,404), but the clinical relevance was minimal after a single bolus (405). A reduction in cortisol was reported 2 hours after delivery in 40 infants whose mothers received etomidate for cesarean section. There were also nine cases of severe to moderate hypoglycemia in this study, but the changes in blood glucose concentration were not significantly different from those in controls (406). 

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