Clinical Laboratory Improvement Act

Miller H I 1988 FDA and biotechnology update 1989 Bio/Technology 6 1385-92 Clinical Laboratory Improvement Act 1992 Fed. Regist. 57 7002-288 Zawisza J 1993 CLIA s impact trouble brewing for IVD clearances Med. Dev. Diagnos. Ind. June 55-9... 

US Department of Health and Human Services. Medicare, Medicaid and CLIA programs regulations implementing the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and Clinical Laboratory Act program fee collection. Federal Register 1993 58 5215-37. 

There are very few tumor types in which the use of chemotherapy can bring about prolonged survival, and possibly cure, for individual patients. The most common reason for this is the development of drug resistance within tumor cells. The laboratory study of resistance to anticancer drugs has resulted in the discovery of numerous mechanisms present within tumor cells that act to reduce their cytotoxic effects. However, the failure to translate this basic laboratory research into improved clinical outcome for patients remains one of the most pressing problems in contemporary cancer research. 

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