Clinical Global Impressions scale

The use of buspirone in social phobia has also been investigated by Schneier et al. [1993]. In this 12-week open trial, 21 patients who met DSM-III-R criteria for social phobia and did not display a response during a 1 -week placebo run-in, went on to receive buspirone. The drug was initiated at 5 mg three times a day and was increased by 5 mg/day every 3 days to a maximum dosage of 60 mg/day or until side effects prevented further dose increases. Seventeen patients completed the trial. At the end of week 12, 8 [47%] of the 17 subjects were rated as much to very much improved on the Clinical Global Impression Scale (Guy 1976]. Of those subjects tolerating doses of 45 mg/day or more, 67% [9/12] were at least much improved. ... 

Abbrevations CGI, Clinical Global Impressions scale SCZ, schizophrenia GAS, Global SczAD (schizoaffective disorder) PANNS, Positive and Negative Syndrome Scale BPRS, Brief Psychiatric Rating Scale SANS, Scale for the Assessment of Negative Symptoms. 

Successful treatment was defined as a Clinical Global Impression scale score of 3, mild, or above, or a score of 4, moderately ill, plus improvement of two plus points from baseline. 

Guy W (1976) The clinical global impression scale. In ECDEU assessment manual for psychopharmacology - revised. US Department of Health, Education, and Welfare, Public Health Service, ADHMHA, NIMH Psychopharmacology Research Branch, Rockville, MD, pp 218-222... 

APA American Psychiatric Association BRS brief psychiatric rating scale CGI Clinical Global Impression (scale)... 

Donepezil Hardan and Handen (2002) Eight autistic children and adolescents (7-19 years) Open trial DSM-IV 50% of subjects had improvement on ABC and Clinical Global Impression Scale. 

Nicolson et al. (2006) Thirteen children (mean age 8.8 years). 12-week open-label trial DSM-IV 61.5% children responded. Improvements in irritability, social withdrawal, emotional lability, inattention, and aggression. ABC, Conners Parent Rating Scale-Revised, Children s Psychiatric Rating Scale and Clinical Global Impressions Scale used. 

---