Clausena anisata alkaloids

Clausena anisata (Willd.) Hook.f.ex Benth. [umnukelambiba, horsewood ] (Rutaceae) stem bark concoction is for cardiac problems. The stem bark contains alkaloids, flavonoids, glycosides, polyphenols, saponins and steroids (75). Extracts of the roots are molluscicidal and the root contains alkaloids and coumarins 16,11). 

Alkaloid from stem bark of Clausena anisata (Rutaceae). Highly active against gram-positive and gram-negative bacteria and fungi. Cryst. Mp... 

O-Demethylmurrayanine (217) C13H9NO2 (M 211), m.p. 237-39° was isolated from stem and root bark of Clausena anisata (55). The uv spectrum 226, 244, 255, 278, 291, 336, 346 nm with log e 4.40,4.51, 4.39,4.59,4.45,4.22,4.22) showed it to be a 3-formyl carbazole derivative. This and colour reactions showed it to be a phenolic carbazole. The H-NMR spectrum indicated the presence of deshielded metacoupled H-4 and H-2 protons, the four protons of the ring A and the proton of the CHO group (89.89). Hence the alkaloid was formulated as l-hydroxy-3-formyl-carbazole. The C-NMR spectrum also support the structure. 

Ngadjui, B.T., J.F. Ayafor, B.L. Sondengam, and J.D. Connolly Quinolone and Carbazole Alkaloids from Clausena anisata. Phytochem. 28, 1517 (1989). 

Nonstructure elucidation of seven pyranocarbazole alkaloids of Murraya koenigii [mahanimbine, koenimbine, (-)-mahanine, koenine, koenigine, koenidine, and ( + )-isomahanimbine] have now been published.Mur-rayacine, a minor alkaloid of the same plant, has been isolated from the roots of Clausena heptaphylla. The stems of another Clausena species, C. anisata Willd., contain atanisatin (1), and the roots contain a second new alkaloid, clausanitin (2). ... 

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