Clausena heptaphylla

Nonstructure elucidation of seven pyranocarbazole alkaloids of Murraya koenigii [mahanimbine, koenimbine, (-)-mahanine, koenine, koenigine, koenidine, and ( + )-isomahanimbine] have now been published.Mur-rayacine, a minor alkaloid of the same plant, has been isolated from the roots of Clausena heptaphylla. The stems of another Clausena species, C. anisata Willd., contain atanisatin (1), and the roots contain a second new alkaloid, clausanitin (2). ... 

The phenolic carbazoles mahanine4b (Id), koenine4b (le), koenigine4b (If), and heptazoline4c (which is 8-hydroxyheptaphyllinela) from Clausena heptaphylla have been characterized by the spectral methods1" now standard for this group. 

Formyl-1-methoxycarbazole (murrayanine) and 3-methylcarbazole (for the first time from natural sources) have been isolated from Clausena heptaphylla Heptazolidine/ a new alkaloid from the same source, has been given the structure (44). Its dihydro-derivative has a u.v. absorption said to be similar to that of 2,3-dimethoxycarbazole. 

CisH,3N03 M 255.273 Alkaloid from leaves of Clausena heptaphylla (Rutaceae). Exhibits antimicrobial activity against both gram-positive and -negative bacteria, and fungi. Needles (C Hg/petrol). Mp 198°. 

Figures in the bracket represent the plant source specified here 1 Murraya koenigii Spreng., 2. M. paniculata L. Jack (Syn. M. exotica Linn.), 3. M. euchrestifolia Hyata., 4. Glycosmis penta-phylla (Retz) D.C., 5. Clausena anisata (Willd) Olive., 6. C. heptaphylla Wt. Arn., 7. C. indica Olive., 8. C. lansium (Lour.) Skeels (Syn. C. wampi Olive.), 9. Micromelum zelynicum, 10. Ekebergia senegalensis.

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