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Class 1 phosphoinositide 3-kinases PI3Ks

Domin J, Harper L, Aubyn D, et al. The class II phosphoinositide 3-kinase PI3K-C2beta regulates cell migration by a PtdIns(3)P dependent mechanism. J Cell Physiol 2005 205(3) 452 162. [Pg.68]

Domin, J. Caidarov, I. Smith, M.E.K. Keen, J.H. Waterfield, M.D. The class II phosphoinositide 3-kinase PI3K-C2a is concentrated in the trans-Colgi network and present in clathrin-coated vesicles. J. Biol. Chem., 275, 11943-11950 (2000)... [Pg.251]

The major products of class I phosphoinositide 3-kinases (PI3Ks) are 3 -phos-phoinositides, most notably phosphatidylinositol 3,4,5-trisphosphate [Ptdlns(3,4,5) P3] which is now recognized as a key signaling molecule. The effects of PI(3,4,5)P3 are... [Pg.53]

S Additional information <4, 8> (<8> the class II phosphoinositide 3-ki-nase C2a is activated by clathrin and regulates clathrin-mediated membrane trafficking [9] <4> TNFa and leptin stimulate the a-isoform of class II phosphoinositide 3-kinase [5] <8> PI3K-C2cr and PI3K-C2/1 represent two downstream targets of the activated epidermal growth factor... [Pg.246]

Additional information <4, 8> (<4> TNFot and leptin stimulate the a-iso-form of class II phosphoinositide 3-kinase [5] <8> interaction with Grb2 dramatically increases catalytic activity. Proline-rich motifs within the N-ter-minus of PI3K-C2/1 mediate the association of this enzyme with activated EGF receptor and this interaction involves the Grb2 adaptor [14]) [5, 14]... [Pg.247]

Figure 3. Pathways of phosphoinositide synthesis and interconversions. The figure shows the main pathways of phosphoinositide synthesis in mammalian cells. For the sake of clarity only the enzymatic activities (3-, 4- or 5-kinases or phosphatases) are indicated. In some cases the identification of key enzymes is mentioned (class I, II and III PI 3-kinases, PTEN, MTM, MTMR or SHIP). PI3K, phosphoinositide 3-kinase. PTEN, phosphatase and tensin homolog deleted on chromosome ten. MTM, myotubularin. MTMR, myotubular myopathy-related protein. SHIP, Src homology 2-containing inositol 5-phosphatase. PLC, phospholipase C. DAG, diacylglycerol. Figure 3. Pathways of phosphoinositide synthesis and interconversions. The figure shows the main pathways of phosphoinositide synthesis in mammalian cells. For the sake of clarity only the enzymatic activities (3-, 4- or 5-kinases or phosphatases) are indicated. In some cases the identification of key enzymes is mentioned (class I, II and III PI 3-kinases, PTEN, MTM, MTMR or SHIP). PI3K, phosphoinositide 3-kinase. PTEN, phosphatase and tensin homolog deleted on chromosome ten. MTM, myotubularin. MTMR, myotubular myopathy-related protein. SHIP, Src homology 2-containing inositol 5-phosphatase. PLC, phospholipase C. DAG, diacylglycerol.
See other pages where Class 1 phosphoinositide 3-kinases PI3Ks is mentioned: [Pg.53]    [Pg.971]    [Pg.190]    [Pg.971]    [Pg.208]    [Pg.189]    [Pg.59]    [Pg.13]    [Pg.53]    [Pg.171]    [Pg.172]    [Pg.181]    [Pg.163]    [Pg.102]    [Pg.65]    [Pg.202]   
See also in sourсe #XX -- [ Pg.52 , Pg.54 ]



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