Cl esterase inhibitor concentrate

Allergic reactions to Cl esterase inhibitor concentrate have been observed, including possible exacerbation of... 

The use of Cl esterase inhibitor concentrate has been associated with transmission of hepatitis C, but this can be prevented by heat treatment (5). 

Nomura S, Hashimoto J, Osawa G. Can Cl esterase inhibitor concentrate be a cause of the exacerbation of hereditary angioneurotic oedema Vox Sang 1995 69(1) 85. 

Despite cases of transmission of hepatitis C associated with intravenous immunoglobulin in the 1990s, no cases of transmission of hepatitis, HIV, or Creutzfeldt-Jakob disease have since been reported with immunoglobulins [6 J. Before 1996, PCCs (prothrombin complex concentrates) were associated with minimal risk of transmission of infective agents [7 ]. There are no documented cases of viral transmission in patients with von Willebrand disease or hemophilia A treated with Haemate P/Humate P in over 25 years of clinical experience in Europe and more than 17 years in the USA [ ]. In the IMPACT-1 and IMPACT-2 trial in 124 patients there were no cases of HIV, hepatitis, or human B19 virus conversion. Furthermore, no cases of viral transmission have been reported during 30 years of post-marketing surveillance of Cl-esterase inhibitor concentrate [9, 10 ]. 

Keating GM. Human Cl-esterase inhibitor concentrate (Berinert). BioDrugs 2009 23 (6) 399 06. 

Craig TJ, Levy RJ, Wasserman RL, Bewtra AK, Hurewitz D, Obtulowicz K, Reshef A, Ritchie B, Moldovan D, Shirov T, Grivcheva-Panovska V, Kiessling PC, Keinecke HO, Bernstein JA. Efficacy of human Cl esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks. J Allergy Clin Immunol 2009 124(4) 801-8. 

Cl Esterase Inhibitor Concentrate fSED-15, 587 SEDA-33, 674 SEDA-34, 512 ... 

Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, et al. Cl esterase inhibitor concentrate in 1085 hereditary angioedema attacks-final results of the 1.M.P.A.C.T.2 study. Allergy December 2011 66(12) 1604-11. 

Hofstra JJ, Kleine Budde I, van Twuyver E, Choi G, Levi M, Leebeek FW, et al. Treatment of hereditary angioedema with nanofiltered Cl-esterase inhibitor concentrate (Cetor(R)) multi-center phase II and III studies to assess pharmacokinetics, clinical efficacy and safety. 

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