Citric Acid-related Polyester Bioelastomers

When designing the poly(diol citrate) bioelastomers including POC, the four rationales have been put forward as follow (1) the use of non-toxic, readily available and inexpensive monomers (2) incorporation of homogeneous biodegradable cross-links to confer elasticity to the resulting materials and leave behind some unreacted functional groups, which could be used for surface modifications (3) the availability of various diols which provided flexibility to 

Weight loss of the POC bioelastomers prepared under different conditions during degradation in phosphate buffer solutions (pH = 7.4, 37 °C). Source Yang et al  

Using other aliphatic diols instead of 1,8-octanediol, such as 1,6-hexanediol, 1,10-decanediol and 1,12-dodecanediol, to react with citric acid by 

By the polycondensation of 1,2-propanediol, sebacic acid and citric acid with no catalyst, the poly((l,2-propanediol-sebacate)-citrate) (PPSC) bioelastomers 

The poly(l,8-octanediol-citrate-sebacate) (POCS) bioelastomers were prepared by condensation of 1,8-octanediol, citric acid and sebacic acid according to the molar ratio of 1 1 [l,8-octanediol/(citric acid -1- sebacic acid)]. The POCS prepolymers were first synthesized at 140-145 °C, then the prepolymers were dissolved in dioxane for obtaining prepolymer solutions finally the prepolymer solutions were cast into the mould and left in an oven at 80 °C for solvent evaporation and further polyesterification to achieve the POCS bioelastomers. Tg of the POCS bioelastomers ranged from -37 to -7 °C. 

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