Citric acid cycle substrate channeling

Substrate Channeling through Multienzyme Complexes May Occur in the Citric Acid Cycle... 

The efficiency of the citric acid cycle may be enhanced by the arrangement of the constituent enzymes. Evidence is accumulating that the enzymes are physically associated with one another to facilitate substrate channeling between active sites. The word metabolon has been suggested as the name for such multienzyme complexes. 

Electrostatic channeling of a substrate between two enzymatic active sites has recently been studied by Brownian dynamics for citric acid cycle enzymes malate dehydrogenase and citrate synthase,and in the bifunctional enzyme... 

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