Cisplatin with loop diuretics

LOOP DIURETICS CISPLATIN t risk of auditory toxic effects with cisplatin Loop diuretics cause tinnitus and deafness as side-effects. Additive toxic effects on auditory system likely Monitor hearing - test auditory function regularly, particularly if patients report symptoms such as tinnitus or impaired hearing... 

The manufacturers consider that the eoneurrent use of nephrotoxic drugs could potentially decrease the elearanee of pemetrexed and therefore increase its toxicity. - In the UK, the manufacturer specifically mentions aminoglycosides, loop diuretics, platinum compounds (see also (a) cisplatin above) and ciciosporin, and recommends caution with combined use, and, if necessary, close monitoring of creatinine clearance. ... 

Decreased magnesium levels, that is, levels of 1.2 mEq/L (0.64 mmol/L) or less, may be noted in patients with conditions that cause excessive urinary loss of magnesium, including poorly controlled diabetes and alcohol abuse, or in patients using drugs such as loop and thiazide diuretics (e.g., Lasix, Bumex, Edecrin, and hydrochlorothiazide), cisplatin (which is used widely to treat cancer), and the antibiotics gentamicin, amphotericin, and cyclosporine. Hypomagnesemia also can... 

---