Glibenclamide Ciprofloxacin

Ciprofloxacin can precipitate hypoglycemia in patients taking glibenclamide. 

There has been a previous report of hypoglycemia in a patient taking glibenclamide and ciprofloxacin (176). 

Hypoglycemia and raised serum concentrations of glibenclamide, which is metabolized by CYP2C9, occurred after treatment with ciprofloxacin for 1 week in a patient taking long-term glibenclamide (72). 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

Ludwig E, Szekely E, Graber H, Csiba A Study of interaction between oral ciprofloxacin and glibenclamide. EurJ Clin Microbiol Infect Dis (1991) 10 (Special issue) 378-9. 

An elderly man with multi-infarct dementia and behavioural disturbances, taking clozapine, glibenclamide (glyburide), trazodone and melatonin, was hospitalised for agitation on the last day of a 10-day course of ciprofloxacin 500 mg twice daily. When the ciprofloxacin course was completed, his plasma clozapine serum levels fell from 90 nanograms/mL to undetectable levels (lower limit of detection being 50 nanograms/mL). ... 

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