Warfarin Ciprofibrate

Clinically important, potentially hazardous interactions with ciprofibrate, cyclosporine, eltrombopag olamine, gemfibrozil, warfarin... 

Clinically important, potentially hazardous interactions with amiodarone, atazanavir, azithromycin, bosentan, ciprofibrate, clarithromycin, clopidogrel, cyclosporine, darunavir, delavirdine, diltiazem, erythromycin, fosamprenavir, fusidic acid, gemfibrozil, grapefruit juice, imatinib, itraconazole, lopinavir, rabeprazole, ranolazine, red rice yeast, ritonavir, roxithromycin, selenium, St John s wort, tacrolimus, telithromycin, tipranavir, verapamil, warfarin... 

In a randomised, placebo-controlled, crossover study, 12 young healthy men were given a single 25-mg dose of warfarin on day 21 of a 26-day course of ciprofibrate 100 mg daily. The ciprofibrate ineieased the anticoagulant response to warfarin by 50% and caused a 28% decrease in the apparent intrinsic clearance of 5-warfarin, which is the more active enantiomer. ... 

Uncertain. Clofibrate can displace warfarin from its plasma protein binding sites, but this does not adequately explain the interaetion. Another suggestion is that the fibrates have an additive pharmacodynamic effect. Altered metabolism may also account for the interaetion with ciprofibrate, since this decreased the clearance of 5-warfarin. However, this did not occur with clofibrate or gemfibrozil. ... 

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See also in sourсe #XX -- [ ]

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