Cinchonidine Subject

Cinchonidine (318) and quinine (319) were subjected to broad-band irradiation in strongly acidic solutions in isopropanol. They were photoreduced to the... 

Spectra for the diastereoisomeric pairs quinine-quinidine, cinchonine-cinchonidine alkaloids are mirror images of each other and mixtures have been determined using CD detection [57]. Spectra for the pilocarpine-isopilocarpine pair were such low quality that they could be used only for qualitative distinction. CD detection combined with UV detection was used to measure enantiomeric excesses in mixtures of L-hyoscyamine and atropine, i.e. racemic hyoscyamine. This subject is returned to in greater depth later. 

Fig. 2. Comparison of the concentrations of quinine, quinidine, cinchonine, and cinchonidine in the plasma of human subjects following ingestion of 10 mg. per kg. doses of these drugs.

Acetyl-6-methoxy-naphthalene may be prepared by the acylation of 6-methoxynaphthalene. The resulting product is then subjected to a series of reactions, namely Wilgerodt-Kindler reaction, esterification, alkylation and hydrolysis ultimately yields /)Z-Naproxen. Resolution of the resulting racemic mixture is caused through precipitation of the more potent /)-enantiomer as the cinchonidine salt. 

Palkowitz and coworkers [15] reported classical resolution of the imidazo-lyl carboxylic acid (1) with (-)-cinchonidine, as part of an integrated approach to triacid angiotensin II antagonists. The (/ )-enantiomer of (1) thus obtained was then subjected to peptidic coupling with amino ester (2), prepared from rran -4-hydroxy-L-proline, a widely available chirality-pool material. 

Fluorescence-based sensing systems offer the possibility of high levels of sensitivity and MIPs containing reporter molecules have been the subject of considerable research. There are two ways in which this may be achieved within MIPs. The simpler of the two is simply imprinting a molecule with inherent fluorescence, as demonstrated by Matsui et al. in the imprinting of cinchonidine and cinchonine. More challenging is the placement of a... 

Action of Alcoholic Potash on the Chlorides." The products formed in these reactions were the subject of a series of papers by Kdnigs and collaborators published in the period 1880-1900. V en cinchonine- or cinchonidine-chloride is heated with alcoholic potash a molecule of hydrogen chloride is split off with the formation of cinchenine cinchene), Cj HgoNg, leaflets, m.p. 128-6°. Similarly quinine- or quinidine-chloride is converted into QuiNENiNE (guvncm), CggHggONg, crystallisiiig in trimetric prisms. 

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