Felodipine Cimetidine

Clinically important, potentially hazardous interactions with amlodipine, bepridil, cimetidine, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil... 

Janzon K, Edgar B, Lundborg P, Regardh CG. The influence of cimetidine and spironolactone on the pharmacokinetics and haemodynamic effects of felodipine in healthy subjects. Acta Pharmacol Toxicol (Coperih) (1986) 59 (Suppl 4), 98. 

The plasma levels of diltiazem, isradipine and nifedipine are increased by cimetidine and it may possibly be necessary to reduce the dosages of these calcium-channel blockers. High doses of cimetidine may increase the bioavailability of lercanidipine. Although studies surest no important interactions occur between nicardipine or nisoldipine and cimetidine, the manufacturers advise caution. Plasma felodipine, lacidipine, nimodipine, and... 

Cimetidine 1 g daily increased the AUC of felodipine 10 mg by 56%, and raised the peak serum level by 54% in 12 subjects. There was a short lasting effect on their heart rates but the clinical effects were minimal. ... 

---