Enoxacin Cimetidine

Drugs that may inhibit cytochrome P450 metabolism of other drugs include amiodarone, androgens, atazanavir, chloramphenicol, cimetidine, ciprofloxacin, clarithromycin, cyclosporine, delavirdine, diltiazem, diphenhydramine, disulfiram, enoxacin, erythromycin, fluconazole, fluoxetine, fluvoxamine, furanocoumarins (substances in grapefruit juice), indinavir, isoniazid, itraconazole, ketoconazole, metronidazole, mexile-tine, miconazole, nefazodone, omeprazole, paroxetine, propoxyphene, quinidine, ritonavir, sulfamethizole, verapamil, voriconazole, zafirlukast, and zileuton. 

Drug interactions The effect of antacids and cations on the absorption of these agents was considered above. Ciprofloxacin, ofloxacin and enoxacin can increase the serum levels of theophylline by inhibiting its metabolism. They also may raise levels of warfarin, caffeine and cyclosporine. Cimetidine interferes with the... 

Cimetidine reduces the metabolic clearance of both enoxacin and pefloxacin by about 20% (134,135). 

Misiak PM, Eldon MA, Toothaker RD, Sedman AJ. Effects of oral cimetidine or ranitidine on the pharmacokinetics of intravenous enoxacin. J Clin Pharmacol 1993 33(l) 53-6. 

Clinically important, potentially hazardous interactions with cimetidine, ciprofloxacin, enoxacin, fluoxetine, fluvoxamine, MAO inhibitors, paroxetine, quinidine, thioridazine... 

Noninterfering adenosine, albuterol, alphenal, aspirin, caffeine, carbamazepine, cefazo-lin, cephalexin, cephalothin, cimetidine, ciprofloxacin, claforan, desipramine, enoxacin, fleroxacin, furosemide, hydralazine, hydrochlorothiazide, minoxidil, norfloxacin, pheny-toin, propafenone, sulindac, teicoplanin, theophylline, vancomycin Interfering some indocyanine green impurities... 

CYP1A2 caffeine, imipramine, paracetamol, theophylline cigarette smoke, omeprazole cimetidine, ciprofloxacin, enoxacin, fluvoxamine... 

Cimetidine can increase the serum levels of some quinolones (intravenous enoxacin or fleroxacin and oral clinafloxacin or pe-floxacin). Famotidine can reduce the serum levels of norfloxacin, and ranitidine can reduce the absorption of enoxacin. None of these interactions appear to be clinically important. 

The plasma levels of a 400-mg intravenous dose of enoxacin were higher when cimetidine 300 mg four times daily was given concurrently. Renal clearance and systemic clearance were reduced by 26% and 20%, respectively, and the elimination half-life was increased by 30%. ... 

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