CIDNP-related Molecular Modelling

Beside successful studies of protein-nucleic acid interactions [19, 21, 22] and protein-folding processes [23] the method has shown to be a proper tool in glyco-sciences since Tyr-, His- and Trp-residues are often constituents of the carbohydrate binding domain [5-7, 15, 24, 25]. Many plant and animal lectins harbour CIDNP-reactive amino acid residues as an essential part of their binding pocket architecture [26-28]. 

Since Tyr-, His- and Trp-residues are CIDNP-responsive and often involved in carbohydrate binding, alterations of the respective signal intensities of lectins can be detected after addition of a specific saccharide. It is possible to correlate such findings with the theoretical results derived by molecular modelling techniques. CIDNP 

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