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Etoposide Ciclosporin

CICLOSPORIN ETOPOSIDE t plasma concentrations of these drugs, with risk of toxic effects Competitive inhibition of CYP3A4-mediated metabolism and P-gp transport of these drugs Watch for toxic effects of these drugs... [Pg.358]

The coadministration of etoposide and high-dose ciclosporin resulted in increased etoposide serum concentrations (153). Lower doses of etoposide were therefore recommended when combined with high-dose ciclosporin. [Pg.3462]

I. ANTIARRHYTHMICS - disopyramide, propafenone 2. ANTIBIOTICS-chloramphenicol, doxycycline, metronidazole, rifampicin, telithromycin 3. ANTICANCER AND IMMUNOMODULATING DRUGS - carmustine, ciclosporin, corticosteroids, doxorubicin, etoposide, ima-tinib, lomustine, paclitaxel, tacrolimus, tamoxifen, toremifene, vinca alkaloids... [Pg.288]

An established and clinically important interaction. Ciclosporin alters the pharmacokinetics of the anthracyclines resulting in increased serum levels. This pharmacokinetic interaction has complicated study into the value of using ciclosporin to modulate multidrug resistance in tumours and thereby improve the response to chemotherapy. In the case of anthracyclines and etoposide , (p.630), any benefit could just be attributed to dose intensification. Consequently, some have suggested reducing the dose of the anthracycline. The use of high-dose ciclosporin for multidrug resistant tumour modulation remains experimental and should only be used in clinical studies. Concurrent use should be very well monitored. More study is needed to find out the possible effects of low-dose ciclosporin. [Pg.612]

High-dose ciclosporin markedly raises etoposide serum levels and increases the suppression of white blood cell production. Severe toxicity has been reported in one patient. [Pg.630]

The leukaemic cells in the bone marrow of a patient with acute T-lym-phocyte leukaemia were totally cleared when ciclosporin 8.3 mg/kg orally twice daily was given with etoposide 100 to 300 mg daily for 2 to 5 days, but the adverse effects were severe (mental confusion, renal and hepatic toxicity). The patient died from respiratory failure precipitated by a chest infection. ... [Pg.630]

A patient with chronic myeloid leukaemia who had responded poorly to treatment with etoposide, mitoxantrone and cytarabine for blast crisis, returned to the chronic phase when given etoposide with ciclosporin. An in vitro study by the same authors showed that etoposide was partially toxic to blast cells but that its effect on blast cells was increased sixfold when it was given with ciclosporin. ... [Pg.630]

It is suggested that the ciclosporin decreases the metabolism of the etoposide by inhibiting its metabolism by cytochrome P450 isoenzymes and inhibiting P-glycoprotein mediated efflux from the hepatocyte, as well as inhibiting some unknown non-renal clearance mechanism. The total effect is to cause the retention of etoposide in the body, thereby increasing its effects. [Pg.630]


See other pages where Etoposide Ciclosporin is mentioned: [Pg.297]    [Pg.297]    [Pg.856]    [Pg.630]    [Pg.630]    [Pg.630]   
See also in sourсe #XX -- [ Pg.630 ]




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