Ciclopirox nail lacquer

Gupta AK, Fleckman P, Baran R. Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis. 

Topical 8% ciclopirox olamine (Penlac nail lacquer) has been approved for the treatment of mild to moderate onychomycosis of fingernails and toenails. Although well tolerated with minimal side effects, the overall cure rates in clinical trials are less than 12%. 

Each gram of PENLAC NAIL LACQUER (ciclopirox) topical solution, 8%, contains 80 mg ciclopirox in a solution base consisting of ethyl acetate, isopropyl alcohol,... 

Ciclopirox (Penlac) nail lacquer for onychomycosis. Med Lett 2000 ... 

Ciclopirox topical (Penlac) solution is a nail lacquer that is PDA approved for the treatment of onychomycosis but demonstrates low complete cure rates. 

Ciclopirox is also sold as a 0.77% gel and a 1% shampoo for the treatment of seborrheic dermatitis of the scalp, and an 8% topical solution (PENIAC NAIL LACQUER) is sold for the treatment of onychomycosis. 

Onychomycosis is a chronic infection that rarely remits spontaneously. Adequate treatment is essential to prevent spread to other sites, secondary bacterial infections, cellulitis, or gangrene. Due to the chronic nature and impenetrability of nails, topical agents have low efficacy rates for treating onychomycosis. Oral agents that can penetrate the nail matrix and nail base, such as itraconazole and terbinafine, are more effective than ciclopirox lacquer. Itraconazole and terbinafine demonstrate mycological cure rates of 62%37 and 76%,38 respectively, while ciclopirox has a cure rate of 29% to 36%.39... 

Management Because of the characteristic physical features of the nail, pharmacokinetics play a major role in therapy [28]. Topical therapy (ciclopirox and amorolfin lacquer), more successful with thin nails and if the lunula is... 

Ciclopirox is a hydroxylated pyridinone that is employed for superficial dermatophytic infections, principally onychomycosis. Ciclopirox has a unique mechanism of action through chelation of polyvalent cations, such as Fe ", which causes inhibition of a number of metal-dependent enzymes within the fungal cell. Although ciclopirox has been available for more than 30 years, a new formulation of an 8% lacquer has been recently introduced for treating nail infections (55). 

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