Cibenzoline

C3H3N 107-13-1) see Calcium pantothenate Cibenzoline Cinolazepam Dihydroxydibutyl ether Indecainide lodoxamic acid Maprotiline Nipradilol Ramatroban Sulfaphenazole Tiquizium bromide... 

H4N2 302-01-2) see Acetazolaraide Allopurinol Brotizolam Carbidopa Cibenzoline Desmopressin Estazolam Etizolam Guanadrel Isoniazid Itraconazole Mitopodozide Niftiroxazide Nifurtimox Nitrofurantoin Phenelzine Primaquine Ziprasidone hydrochloride hydrazine-1,2-bis(thiocarbaxamide)... 

Class la (action potential wider) Procainamide Disopyramide Cibenzoline Quinidine... 

Fig. 1. Summary of the most important actions of antiarrhythmic drugs on membrane channels, receptors, and ionic pumps in the heart. The drugs are arranged in a fashion similar to the columns, so that generally the entries for their predominant actions form a diagonal. Most of these drugs are already available in Europe and the USA, but aprindine, pirmenol, cibenzoline, and pilsicainide are only available in Japan. (Reproduced with permission from Ogawa et al., 1997.)...

A 65-year-old woman developed hypoglycemia while taking cibenzoline and alacepril (268). 

It is possible that hypoglycemia due to cibenzoline can be enhanced by ACE inhibitors, which can increase insulin sensitivity (SED-14, 640). 

Jeandel C, Preiss MA, Pierson H, Penin F, Cuny G, Bannwarth B, Netter P. Hypoglycaemia induced by cibenzoline. Lancet 1988 l(8596) 1232-3. 

Gachot BA, Bezier M, Cherrier JF, Daubeze J. Cibenzoline and hypoglycaemia. Lancet 1988 2(8605) 280. 

Takada M, Fujita S, Katayama Y, Harano Y, Shibakawa M. The relationship between risk of hypoglycemia and use of cibenzoline and disopyramide. Eur J Clin Pharmacol 2000 56(4) 335-42. 

Ogimoto A, Hamada M, Saeki H, Hiasa G, Ohtsuka T, Hashida H, Hara Y, Okura T, Shigematsu Y, Hiwada K. Hypoglycemic syncope induced by a combination of cibenzoline and angiotensin converting enzyme inhibitor. Jpn Heart J 2001 42(2) 255-9. 

CnH oN2 883-40-9) see Benzatropine Cefbuperazone Cefixime Cefoxitin t i.v-Cefprozil Cibenzoline Latamoxef (/LS, /f,S)-I,2-diphenyl-l- 4- 2-(dimethylamino)ethoxy] phenyl Jbutane-1,4-diol (CmH., NO, 141854-25-3) see Toremifenc (Z)-l,2-diphenyl-l-[4-(2-(dimcthylamino)ethoxy)phenyl -... 

Cibenzoline Gastrointestinal and nervous system effects hypoglycemia... 

There is some anecdotal evidence that atrioventricular nodal blockade with verapamil or a beta-blocker can also be effective. However, in two cases the addition of a beta-blocker (either atenolol or metoprolol) to treatment with class I antidysrhythmic drugs (cibenzoline in one case and flecainide in the other) did not prevent the occurrence of atrial flutter with a 1 1 response (47). However, the author suggested that in these cases, although the beta-blockers had not suppressed the dysrhythmia, they had at least improved the patient s tolerance of it. In both cases the uses of class I antidysrhythmic drugs was contraindicated by virtue of structural damage, in the first case due to mitral valvular disease and in the second due to an ischemic cardiomyopathy. 

Cibenzoline prolongs the PR interval, the QRS interval, and the QT interval (4—7). It also prolongs the AH and HV intervals (5,8) and shortens the sinus cycle length (5-8). Because of these effects it can cause dysrhythmias (4,6,7,9). 

Cardiac dysrhythmias have been attributed to cibenzoline in a 60-year-old man with hypertrophic cardiomyopathy (10). 

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