Ranitidine Cibenzoline

Cimetidine increases the plasma levels of cibenzoline, but ranitidine does not interact. 

Cimetidine 1.2 g daily raised the maximum plasma levels of a single 160-mg dose of cibenzoline in 12 healthy subjects by 27%, increased the AUC by 44%, and prolonged its half-life by 30%. Ranitidine 300 mg daily had no effect. The probable reason is that cimetidine, an enzyme inhibitor, reduces the metabolism of the cibenzoline by the liver, whereas ranitidine, bich has little enzyme inhibiting etfects, does not. The clinical importance of this interaction is not known but be alert for increased cibenzoline effects. 

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