Chronic conditions, disease groups

A wide range of conditions fall into this gronp. They can be roughly categorised further into those causing cholestatic disease, chronic liver disease, acute liver failure/metabolic crisis, storage disorders, disorders of bilirubin metabolism. Table 3.5 snmmarises the types of liver disease that fall into each group. 

Like the other conditions discussed above, patients with COPD have a higher prevalence of hypogonadism than their healthier counterparts [240]. Chronic steroid use may exacerbate muscle loss and weakness in this group. Although unproven, treatment of these symptoms with a SARM could offer considerable improvement of quality of life in these patients as well as those who are treated with chronic corticosteroids for rheumatologic or other inflammatory diseases. These are examples of chronic conditions where decades of anabolic therapy may be needed. An anabolic agent that reduces the morbidity and mortality associated with these conditions without unwanted effects would serve a huge unmet need in this patient population. 

The details depend, of course, very much on the age group 1-4,5-14,15-24,25-44,45-64,65-74, and 75-. .. 121 In the United States the age group of 25 to 44 (all races and both sexes combined) will most likely die of accidents (27,182 deaths—but including medical accidents see below), cancer (20,436 deaths), heart disease (16,139 deaths), suicide (11,354 deaths), HIV (8,356 deaths), homicide (7,383 deaths), chronic liver disease (3,786 deaths), cerebrovascular diseases (3,201 deaths), diabetes mellitus (2,549 deaths), and pneumonia and influenza (1,068 deaths). At 1 to 4 years old, accidents (1,826 deaths) still dominate, but this is followed by congenital defects (495), cancer (420), homicide (356), heart disease (181), pneumonia and influenza (103), septicemia (99), prenatal conditions (79), so-called Benign neoplasm (i.e., simply meaning that they don t spread) (53), and lower respiratory diseases (51). For age 75 and up, it will be heart disease (471,302), cancer (242,235), cerebrovascular diseases (124,396), lower respiratory diseases (75,218), pneumonia and influenza (51,368), Alzheimer s disease (45,462), diabetic mellitus (35,470), nephritis (24,235), accidents (23,353), and septicemia (19,082). 

Particulates that are small enough to find their way into the lungs and remain there, including dusts fine enough to be classified as respirable dusts, can produce serious chronic conditions such as the group of diseases known as pneumoconiosis— lung diseases Uke coal miners black lung disease and silicosis. 

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