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Protein scaffold eukaryotic chromosomes

Each eukaryotic chromosome contains a single DNA molecule packaged into nucleosomes and folded into a 30-nm chromatin fiber, which is attached to a protein scaffold at specific sites (see Figure 10-24). Additional folding of the scaffold further compacts the structure into the highly condensed form of metaphase chromosomes. [Pg.430]

Nucleosomes are organized into 30 nm fibers, and the fibers are extensively folded to provide the 10,000-fold compaction required to fit a typical eukaryotic chromosome into a cell nucleus. The higher-order folding involves attachment to a nuclear scaffold that contains histone HI, topoisomerase II, and SMC proteins. [Pg.945]

Eukaryotic chromosomes are formed from linear DNA. The DNA is wrapped around specialized proteins known as histone scaffolds then it is folded into loops and is wrapped into minibands, and finally it is stacked as chromosomes. DNA in chromosomes is usually maintained in a slightly negative supercoil (Chap. 8). [Pg.226]

Topoisomerases are recruited for enabling topological motions to occur. In condensed eukaryotic chromatin, loops of 300 A fiber are attached to a scaffold. Topoisomerases are a major component of the proteins that make up the chromosome scaffold. Although the DNA of mammalian chromosomes is linear, these frequent attachment points make each constrained loop into topologically circular. [Pg.453]


See other pages where Protein scaffold eukaryotic chromosomes is mentioned: [Pg.75]    [Pg.429]    [Pg.45]    [Pg.53]    [Pg.204]    [Pg.211]    [Pg.99]    [Pg.584]    [Pg.324]    [Pg.112]    [Pg.19]   
See also in sourсe #XX -- [ Pg.155 , Pg.156 ]




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