Chromatoid aberrations

An investigation of the effect of dithiocarbamates on the chromosomes of bone marrow cells showed that ziram and, particularly, TMTD causes chromosomal aberrations. The effect of ethylenebisdithiocarbamates is considerably milder. All of the aberrations produced by these compounds were of the chromatoid type (Kurinnyi and Kondratenko, 1972). 

Benzene and its metabolites have long been known to cause chromosomal aberrations of various types of cell cultures of exposed humans. (To be discussed in Chapter 20.6 in fliis book entitled as Benzene Exposure and Sister Chromatoid Changes.) While it is true fliat genetic changes have been described and frequently effect chromosomes 5 and 7, and ofli-ers, there is no scientific evidence that these are required for the diagnosis of benzene exposure related cancers. Specifically, many cases of patients who have been exposed to... 

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