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Chromatographic mode selection HPLC method development

The PRISMA model was developed by Nyiredy for solvent optimization in TLC and HPLC [142,168-171]. The PRISMA model consists of three parts the selection of the chromatographic system, optimization of the selected mobile phases, and the selection of the development method. Since silica is the most widely used stationary phase in TLC, the optimization procedure always starts with this phase, although the method is equally applicable to all chemically bonded phases in the normal or reversed-phase mode. For the selection of suitable solvents the first experiments are carried out on TLC plates in unsaturated... [Pg.866]

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Chromatographic methods

Chromatographic methods HPLC)

Chromatographic modes

Chromatographic selection

Chromatographic selectivity

Developer selectivity

Development chromatographic

Development modes

HPLC chromatographic

HPLC methods

HPLC methods development

Method development

Method selection

Method selectivity

Mode selection

Mode-selectivity

SELECT method

Selective development

Selective methods

Selectivity HPLC development

Selectivity development

Selectivity method development

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