Chromatographic analysis optimization function

Derivatization is the most studied sample preparation method for the chromatographic analysis of environmental samples (Figure 2.6). It is a sample preparation process in which analytes are chemically modihed in order to optimize their possibility of separation and detection by chromatographic techniques. The aim of derivatization depends on the nature of analytes and it has different purposes as a function of chromatographic techniques used (GC or HPLC). Derivatization in GC is used in order ... 

It has also proven advantageous to use a combination of individual responses in order to optimize as many parameters as possible (39-43). The two performance goals for a separation of bisphenols by MEKC were good resolution among five peaks and short total analysis time (42). Thus, a chromatographic response function (CRF) was employed that was a product of two types of desirability functions, as used by Divjak et al. (30-33, 44). Resolution (R) between two adjacent peaks in an electropherogram was calculated using... 

---