Chromatin remodeling initiation

Figure 1. Schematics of the effect of mH2A on transcription, (a) The mobiUzation of conventional promoter nucleosome by the chromatin remodeling complex generated a nucleosome-free promoter, which allowed the binding of the transcription factors and transcription to proceed, (b) MacroH2A nucleosome cannot be mobilized by die chromatin remodeling complex and die transcriptions factors are unable to bind macroH2A nucleosome containing promoter, which results in inhibition of the initiation of transcription. (See Colour Plate 8.)...

Dilworth FJ, Chambon P. 2001. Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription. Oncogene 20 3047-54... 

Koche RP et al (2011) Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell 8(1) 96-105... 

SWI/SNF chromatin-remodeling factors constitute another type of co-activator. These multisubunit complexes can transiently dissociate DNA from histone cores in an ATP-dependent reaction and may also decondense regions of chromatin, thereby promoting the binding of DNA-binding proteins needed for initiation to occur at some promoters. 

Once a gene is activated through chromatin remodeling, the major mechanism of regulating expression affects initiation of transcription at the promoter. 

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