Chorismate pathway

Shepheridin 2 486 Shikamate-chorismate pathway 943 Short tandem repeat 277 shRNA (short hairpin RNA) 243, 247, 573 Shuttle vector 156 Sical 477 slD direct 255 slFect system 632... 

Figure 5 The shikimate-chorismate pathway. DAHP, 3-deoxy-o-arabino-2-heptulosonate-7-phosphate EPSP,...

Amino acid biosynthesis is often regulated by the end products of a given pathway to control the relative amounts of amino acids being produced. Aromatic amino acid biosynthesis thus far is known to be feedback regulated at three points in the shikimate/chorismate pathway. The initial step is catalyzed by 3-deoxy-D-arabino-2-heptulosonate-7-... 

The studies of the origin of GHB in A. bisporus demonstrated the involvement of the shikimate-chorismate pathway (Scheme 102). Labeling experiments showed an efficient incorporation of H- and C-labeled shikimic acid 439,440) and C-labeled chorismic acid 441) into the 4-hydroxyaniline moiety of GHB. It was also demonstrated that in the biochemical shikimate-4-hydroxyaniline conversion in the mushroom, amination occurred at the 4 position of one of the carboxylic acid intermediates [initially assumed to be shikimic acid 439)]. Additionally, the p-aminobenzoic acid, which proved to be 441) the precursor of 4-hydroxyaniline, underwent a decarboxylative hydroxylation catalyzed by a FAD-dependent monooxygenase 4-aminobenzoate hydroxylase in the presence of NAD(P)H and O2. This enzyme from A. bisporus was recently purified to homogeneity by Tsuji et al. 442). 

Miscellaneous Compounds Which May he Derived from the Shikimate-Chorismate Pathway... 

Secondary Metabolites Derived Through the Shikimate-Chorismate Pathway. In The Filamentous Fungi (J.E. Smith and D.R. Berry, eds.) Vol. II, p. 460-473. London E. Arnold. 1976. 

Aromatic biosynthesis, aromatizatioa biosynthesis of compounds containing the benzene ring system. The most important mechanisms are 1. the shi-kimate/chorismate pathway, in which the aromatic amino acids, L-phenylalanine, L-tyrosine and L-trypto-phan, 4-hydroxybenzoic acid (precursor of ubiquinone), 4-aminobenzoie acid (precursor of folic acid) and the phenylpropanes, including components of lignin, cinnamic acid derivatives and flavonoids are synthesized and 2. the polyketide pathway (see Polyke-tides) in which acetate molecules are condensed and aromatic compounds (e.g. 6-methylsalicylic acid) are synthesized via poly-fl-keto acids. Biosynthesis of flavonoids (e.g. anthocyanidins) can occur by either pathway. 

Three different metabolic pathways are known to be involved in the synthesis of different classes of phenolic compounds, namely, (1) (Ce — C3) phenylpropanoid derivatives produced by the shikimate/chorismate pathway (2) side chain elongated phenylpropanoids, flavonoids (Ce - C3 - Cg), and few quinones synthesized by the acetate/malOTiate or polyketide pathway and (3) the aromatic terpenoids synthesized throu the acetate/mevalonate pathway. 

EXAMPLES FROM THE SHIKIMATE-CHORISMATE PATHWAY MORE INSIGHT, LESS PROOF... 

Anthraquinone pigments in madder are biosynthesised by the shikimate (chorismate) pathway, which provides only anthra-9,10-quinones. The starting compound is naphtho-l,4-quinone-2-carboxyhc acid. 

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