Cholinergic hypothesis of Alzheimer

The cholinergic hypothesis of Alzheimer s disease evolved out of some of the earliest chemical and molecular observations made about the disease... 

Francis PT, Palmer AM, Snape M, The cholinergic hypothesis of Alzheimer s disease A review of progress, J Neurol Neurosurg Psychiatry 66 137—147, 1999. 

THE CHOLINERGIC HYPOTHESIS OF ALZHEIMER S DISEASE AND CHOLINERGIC ENHANCEMENT STRATEGIES... 

The cholinergic hypothesis of Alzheimer s disease postulates that... 

Robbins TW, McAlonan G, Muir JL, Everitt BJ. (1997). Cognitive enhancers in theory and practice studies of the cholinergic hypothesis of cognitive deficits in Alzheimer s disease. Behav Brain Res. 83(1-2) 15-23. 

Amyloid cascade hypothesis of Alzheimer s disease. A leading contemporary theory for the biological basis of Alzheimer s disease centers around the formation of beta amyloid. Certainly much of this amyloid destroys cholinergic neurons in the nucleus basalis of Meynert (Fig. 12—11), although the damage becomes more widespread as the disease progresses (Fig. 12-13). Hypothetically, Alzheimer s disease is a disorder in which beta amyloid deposition destroys neurons, in a manner somewhat analogous to that in which the abnormal deposition of cholesterol causes atherosclerosis. Thus,... 

Terry AV, Buccafusco JJ. The cholinergic hypothesis of age and Alzheimer s disease-related cognitive deficits recent challenges and their implications for novel drag development. J Pharmacol Exp Ther 2003 306 821-827. 

Davidson JRT, Eord SM, Smith RD, et al Long-term treatment of social phobia with clonazepam. J Clin Psychiatry 52 (suppl) 16-20, 1991b Davidson JRT, Potts N, Richichi E, et al Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol 13 423-428, 1993 Davies P Theoretical treatment possibilities for dementia of the Alzheimer type the cholinergic hypothesis, in Strategies for the Development of an Effective Treatment for Senile Dementia. Edited by Crook T, Gershon S. New Canaan, CT, Mark Powley Associates, 1981, pp 19-32... 

Alzheimer s disease is characterized by a progressive impairment of cognitive functions including the loss of memory and the inability to perform basic daily life (56). Based on the cholinergic hypothesis, these symptoms are the results of the reduction in brain acetylcholine activity due to the catabolism of acetylcholine by ACHE (57). 

Hardy JA, Higgins GA. Alzheimer s disease the amyloid cascade hypothesis. Science. 1992 256(5054) 184-185. Zheng WH, Bastianetto S, Mennicken F, Ma W, Kar S. Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures. Neuroscience. 2002 115(1) 201-211. van Echten-Deckert G, Walter J. Sphingolipids critical players in Alzheimer s disease. Prog Lipid Res. 2012 51(4) 378-393. 

---