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Choline acetyltransferase cerebellum

Kan K-S, Chao L-P, Eng LF (1978) Immunohistochemical localization of choline acetyltransferase in rabbit spinal cord and cerebellum. Brain Res 146 221 -229. [Pg.35]

Biochemical measurement of distinct levels of acetylcholine (McIntosh, 1941 Kasa et al., 1982) and its biosynthetic enzyme, choline acetyltransferase (ChAT) in cerebellar tissue (Kasa and Silver, 1969 Salvaterra and Foders, 1979 Hayashi, 1987 and others) indicated the presence of a cholinergic innervation in the cerebellum. ChAT activity varies among different lobules with the highest levels in the nodulus and ventral uvula. Following deafferentation of the cerebellar cortex, ChAT activity is considerably de-... [Pg.113]

Fig. 84. Illustrations of choline-acetyltransferase (ChAT)-like immunoreactivity in the rabbit cerebellum. A. Sagittal view of the rabbit cerebellum delineating the lobules according to Larsell (Larsell, 1970). Mean measurements of ChAT activity are indicated by numbers in parentheses. B. Magnified view of the ventral vermis. The vermis contains areas of ChAT-positive mossy fiber terminals (indicated by dots). These areas in lobules 1 and 9d are illustrated in C and D, respectively. E. View of the right paraflocculus of the rabbit. ChAT-like immunoreactivity and ChAT activity was highest in the ventral paraflocculus, particularly lobule 2. The numbers in parentheses are mean measurements of ChAT activity, expressed as mmol of Ach synthe-sized/hr. g tissue at 37°C, for each cerebellar lobule in six rabbits. Barmack et al. (1992a). Fig. 84. Illustrations of choline-acetyltransferase (ChAT)-like immunoreactivity in the rabbit cerebellum. A. Sagittal view of the rabbit cerebellum delineating the lobules according to Larsell (Larsell, 1970). Mean measurements of ChAT activity are indicated by numbers in parentheses. B. Magnified view of the ventral vermis. The vermis contains areas of ChAT-positive mossy fiber terminals (indicated by dots). These areas in lobules 1 and 9d are illustrated in C and D, respectively. E. View of the right paraflocculus of the rabbit. ChAT-like immunoreactivity and ChAT activity was highest in the ventral paraflocculus, particularly lobule 2. The numbers in parentheses are mean measurements of ChAT activity, expressed as mmol of Ach synthe-sized/hr. g tissue at 37°C, for each cerebellar lobule in six rabbits. Barmack et al. (1992a).
Fig. 85. A. Drawing displaying the distribution of mossy rosettes (dots) immunoreactive to monoclonal choline-acetyltransferase (ChAT) antibody. The section (40 fim thick) was cut sagittally through the middle vermis of rat cerebellum. A considerable number of immunoreactive mossy terminals are observed in lobules I through IXab, although they are much fewer than in lobules IXc and X. Calibration bar = 1 mm. B. Drawing of part of lobule IXab shows the overall distribution of immunoreactive fibers. Arrows indicate mossy fibers with glomerular rosettes. Small and large arrowheads point to some varicose fibers distributing in or near the Purkinje cell layer (PCL) and in the molecular layer (ML), respectively. The ML fibers are most frequently observed in this lobule and tend to be restricted to the inner half of the layer. Calibration bar = 200 jum. Ojima et al. (1989). Fig. 85. A. Drawing displaying the distribution of mossy rosettes (dots) immunoreactive to monoclonal choline-acetyltransferase (ChAT) antibody. The section (40 fim thick) was cut sagittally through the middle vermis of rat cerebellum. A considerable number of immunoreactive mossy terminals are observed in lobules I through IXab, although they are much fewer than in lobules IXc and X. Calibration bar = 1 mm. B. Drawing of part of lobule IXab shows the overall distribution of immunoreactive fibers. Arrows indicate mossy fibers with glomerular rosettes. Small and large arrowheads point to some varicose fibers distributing in or near the Purkinje cell layer (PCL) and in the molecular layer (ML), respectively. The ML fibers are most frequently observed in this lobule and tend to be restricted to the inner half of the layer. Calibration bar = 200 jum. Ojima et al. (1989).
Barmack NH, Baughman RW, Eckenstein FP (1992a) Cholinergic innervation of the cerebellum of rat, rabbit, cat, and monkey as revealed by choline acetyltransferase activity and immunohistochemistry. J. Comp. Neurol., 317, 233-249. [Pg.314]

Gould E, Butcher LL (1987) Transient expression of choline acetyltransferase-like immunoreactivity in Purkinje cells of the developing rat cerebellum. Dev. Brain Res., 34, 30,3-306. [Pg.331]

Ikeda M, Houtani T, Ueyama T, Sugimoto T (1991) Choline acetyltransferase immunoreactivity in the cat cerebellum. Neuroscience, 45, 671-690. [Pg.336]

Kasa P, Silver A (1969) The correlation between choline and acetyltransferase and acetylcholinesterase activity in different areas of the cerebellum of rat and guinea pig. J. Neurochem., 16, 386-396. [Pg.338]

See other pages where Choline acetyltransferase cerebellum is mentioned: [Pg.174]    [Pg.273]    [Pg.274]    [Pg.23]    [Pg.117]    [Pg.287]    [Pg.327]    [Pg.551]    [Pg.140]   
See also in sourсe #XX -- [ Pg.113 ]



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