Cholesterol statins

Combination drug therapy is an effective means to achieve greater reductions in LDL cholesterol (statin + ezetimibe or bile acid resin, bile acid resin + ezetimibe, or three-drug combinations) as well as raising HDL cholesterol and lowering serum triglycerides (statin + niacin or fibrate). 

Reducing LDL cholesterol while substantially raising HDL cholesterol (statin + niacin) appears to reduce the risk of atherosclerotic disease progression to a greater degree than statin monotherapy. 

Statins are compounds that inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, and they are the world s best-selling drugs and are used for lowering cholesterol. Statins are well studied and are believed to be quite safe. Because they reduce the levels of cholesterol, the precursor of the bile acids, statins may be the ideal drugs to use for BA-loweiing in these GI tract diseases. 

Risk of cardiovascular events LDL HDL serum cholesterol Statins... 

Statins, used predominantly in the treatment of hypercholesterolemia, act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which regulates the synthesis of cholesterol. Statins are also agonists of peroxisome proliferator activated receptors (PPARs), which are part of the nuclear receptor superfamily and when activated, can suppress transcription of pro-inflammatory genes (Chinetti et al., 2000). In vitro and in vivo studies have shown that a decrease in serum cholesterol inhibits the production of beta amyloid and plaque (Simons et al., 1998 Fassbender et al.,... 

Developed to control elevated low density lipoprotein cholesterol, statins [the inhibitors of 3-hydroxy-3-methylglutary 1-CoA (HMG-... 

Beyond Cholesterol Statin Benefits in Alzheimer s Disease... 

Soares HD, Sparks DL (2007) Beyond Cholesterol Statin Benefits in Alzheimer s Disease. 2 ... 

Keywords dyslipidaemia, LDL-cholesterol, small dense LDL, HDL-cholesterol, statins, fibrates, ezetimibe, nicotinic acid. 

Kirsch C, Eckert GP, Muller EE (2003) Brain cholesterol, statins and Alzheimer s Disease. Pharmacopsychiatry 36(Suppl 2) S113-S119... 

Runhua H, Anne Carol G. FACP. Lowering low-density Hpoprotein cholesterol statins, ezetimibe, bile add sequestrants, and combinations comparative efficacy and safety. End and Metab Chn North Am 2009 38 79-97. 

In addition to the enzyme inhibitors produced by fungi used to lower cholesterol (statins), several bacterial enzyme inhibitors have also been studied for potential utilization in medicine. The most important is clavulanic acid, the inhibitor of p-lactamases discussed above in the section Search for New Antibiotics in the Following Decades. ... 

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