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Cholesterol childhood levels

This effect may be due to decreasing hepatic cholesterol and cholesterol ester levels to such an extent that hepatic formation of VLDL is impaired. The statins also have been claimed to reduce blood cholesterol levels modestly in some patients with homozygous familial hypercholesterolemia, a condition often fatal in childhood or in early adulthood. [Pg.271]

This is an inherited disorder in which individuals have a lack of functional LDL receptors preventing cholesterol from being taken up by the tissues. The resulting high blood cholesterol level leads to an increase in the formation of atheromas and can cause death from myocardial infarction during childhood. [Pg.340]

Vitamin D is a fat soluble vitamin related to cholesterol. In the skin, sunlight spontaneously oxidizes cholesterol to 7-dehydrocholesterol. 7-Dehydrocholesterol spontaneously isomerizes to cholecalciferol (vitamin D3), which is oxidized in the liver to 25-hydroxy cholecalciferol and, under the influence of PTH in the kidney, to 1,25-dihy-droxy cholecalciferol (calcitriol), the active form of vitamin D. Vitamin D induces the expression of calcium ion transport proteins (calbindins) in intestinal epithelium, osteoclasts, and osteoblasts. Calbindins and transient receptor potential channels (TRPV) are responsible for the uptake of calcium from the diet. In children, the absence of sunlight provokes a deficiency of vitamin D, causing an absence of calbindins and inadequate blood calcium levels. Osteoid tissue cannot calcify, causing skeletal deformities (rickets). In the elderly, there is a loss of intestinal TRPV receptors and decreased calbindin expression by vitamin D. In both cases, the resultant low blood calcium levels cause poor mineralization during bone remodeling (osteomalacia). Rickets is the childhood expression of osteomalacia. Osteoclast activity is normal but the bone does not properly mineralize. In osteoporosis, the bone is properly mineralized but osteoclasts are overly active. [Pg.171]


See other pages where Cholesterol childhood levels is mentioned: [Pg.782]    [Pg.175]    [Pg.4]    [Pg.827]    [Pg.793]    [Pg.342]    [Pg.153]    [Pg.1062]    [Pg.1080]    [Pg.1095]    [Pg.445]    [Pg.732]    [Pg.747]    [Pg.756]    [Pg.437]    [Pg.320]    [Pg.827]    [Pg.350]    [Pg.326]    [Pg.164]    [Pg.267]    [Pg.419]    [Pg.175]   
See also in sourсe #XX -- [ Pg.461 ]




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Childhood

Cholesterol levels

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