Cholestatic liver disease transport

Zollner, G. et al. (2001) HepatobUiary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology, 33 (3). 633-646. 

Taken together, FXR not only regulates bile acid homeostasis but also greatly impacts on transporters and enzymes involved in drug metabolism. Effects on phase I—III genes by bile acid-activated FXR may therefore at least in part explain alterations of drug metabolism in cholestatic liver disease [62, 85, 86]. 

Bohan, A. and Boyer, J.L. (2002) Mechanisms of hepatic transport of drugs implications for cholestatic drug reactions. Seminars in Liver Disease, 22, 123-136. 

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