Antagonist cholecystokinin

Some amino derivatives 32c-g containing an indolylmethyl substituent were prepared as potential cholecystokinin antagonists by Method A.231... 

Various 1.4-benzodiazepines with a five-membered heteroaromatic ring fused to the 1,2-bond, such as 17, where A represents a heteroaromatic ring, have been prepared by such methods and tested for activity on the central nervous system, as cholecystokinin antagonists and as antagonists of platelet activating factors.245... 

Herranz R. Cholecystokinin antagonists pharmacological and therapeutic potential. Med Res Rev 2003 23 559-605. 

Evans BE, Rittle KE, Bock MG, et al. (1988) Methods for drug discovery Development of potent, selective, orally effective cholecystokinin antagonists. /. Med. Chem. 31 2235-2246. 

Cortisol antagonists Cholecystokinin antagonists Ovulation suppressors Antiestrogens ... 

Woodruff GN, Hughes J Cholecystokinin antagonists. Annu Rev Pharmacol Toxicol 31 469-501, 1991... 

Froetschel, M.A., Azain, M.J., Edwards, G.L., Barb, C.R., and Amos, H.E. 2001. Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats. J. Nutr. 131, 3270-3276. 

Proglumide (Milid) acts as a cholecystokinin antagonist, blocking both the CCKa and CCKb subtypes. It was used mainly in the treatment of stomach ulcers but has now been largely replaced by newer drugs. 

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