Cholecystokinin agonists/antagonists

Cholecystokinin. Cholecystokinin (CCK) is also colocalized with dopaminergic neurons and has two receptor subtypes, CCK-A being predominantly outside of and CCK-B within the central nervous system. Studies of CCK agonists and antagonists to date have not given clear clues as to their potential for therapeutic actions in schizophrenia. 

Tifluadom is a 2-[(acylamino)methyl]-l,4-benzodiazepine (Fig. 8), with K-agonist and cholecystokinin-A (CCK-A) antagonist abilities [29]. Cappelli and colleagues successfully discriminated KORs from CCKs, and KORs from MORs using the 2-[(acylamino)ethyl] derivatives [29, 31]. Although tifluadom is a racemic... 

Cholecystokinin (CCK) is one of a number of peptides that act both as gut hormones and neurotransmitters in the central nervous system (CNS). Through the discovery of selective agonists and antagonists it has been possible to show that CCK acts through at least two receptor subtypes, CCK-A and CCK-B. The former are found mainly in the periphery, whilst the latter are located extensively in the CNS. 

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