Choladienic Acid

Methyl ester of A -7-ketocholenic acid A -Choladienic acid (after hydrolysis) D 90% 168... 

The steroid nucleus of bile acids can also be modified by intestinal organisms, the reaction generally requiring a 3-keto substituted bile acid as substrate (Figure 2). Under strictly anaerobic conditions some Clostridia can convert 3-oxo-cholanic acid to 3-oxo-4-cholanic acid, 3-oxo-l-cholanic acid or 3-oxo-l, 4-choladienic acid and 3-oxo-7a-hydroxy-choladienic acid to 3-oxo-4, 6-cholanic acid. Although this reaction proceeds readily in vitro unsaturated substrates have yet to be reliably identified in feces. 

Hydroxyindole, 941 Hydroxyisomytilitol, 326 Hydroxyisophorone, 1176-1177 2-Hydroxyisophthalic acid, 533 3a-Hydroxy-l 2-keto-A h >.choladienic... 

Aeylaerylic esters structures from /3-keto sulfoxides by reaction of methyl esters with dimsyl-potassium (method of Corey, 1, 311). The steps are outlined in equations (1) and (II). This method was used to prepare the isocardenolide 3 acetoxy-20-hydroxy-21-nor-5,22-choladiene-24-oic acid y-lactone from methyl 3)J-hydroxy-ctienate in excellent yield. 

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