Chlorpheniramine Maleate Solution

Pharmaceutical grade ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate, nipagen and syrup preparation were kindly supplied by Berko tlag Sanayi A. , Istanbul. 0.03 M H PO and KH PO solutions were prepared with analytical grade chemicals and milliQ water. HPLC grade acetoiutrile was used. 

Appropriate amount of stock solutions were mixed and diluted with water-acetonitrile (50 50) to obtain the final concentration of 1,000, 150, 10 and 50 ppm for ibuprofen, pseudoephedrine HCl, chlorpheniramine maleate and nipagen. 

Fig. 2 Disappearance profiles of (A) tetrahydrozoline hydrochloride and (B) chlorpheniramine maleate from rat nasal cavity after nasal administration of an o/w emulsion and an aqueous solution at pH 8. (From Ref. l)...

Cough-cold preparations Paracetamol, dextromethorphan hydrobromide and chlorpheniramine maleate in antitussive syrups Partition Permaphase ODS Methanol/buffer solution... 

Eckhart CG and McCorkle T, Chlorpheniramine maleate, APDS, 1, 53 (1978). NB See Perrin DD, Dissociation constants of organic bases in aqueous solutions, Butterworths, London (1965). 

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