Chlorothiazide Chlorpromazine

Several drug classes, including tetracycline, sulfonamide, and quinolone antibiotics, as well as chlorothiazide, chlorpromazine, and amiodarone hydrochloride, have been shown to be photoantigens. Photosensitivity may persist even after withdrawal of the drug, as has been observed with the antiarrhythmic drug amiodarone hydrochloride, since it is lipophilic and can be stored for extended periods in the body fat (Unkovic et al., 1984). In addition, it is quite common for cross-reactions to occur between structurally related drugs of the same class. 

Albumin X 4 X X HIV protease inhibitors, atenolol, cimetidine, chlorothiazide, chlorpromazine, losartan, phenytoin, tamoxifen, warfarin Aungst et al., 2000... 

Cefadroxi1, 440 Cefamandole, 441 Cefazolin, 442 cefoxitin, 435, 443 Cephalexin, 439 Cephamycin C, 442 Cephradine, 440 Cephapirin, 441 Cetophenicol, 46 Chioramphenicol, 28, 45 Chlordiazepoxide, 401 Chlormadinone acetate, 165 p-Chlorophenylalanine, 52 Chlorothiazide, 395 Chlorpromazine, 409 Cholinergic transmission, 71... 

For instance, blurring of vision and diplopia are caused by the use of imipramine, iproniazid, chlorpromazine, thioridazine, and promethazine. Impairment of visual acuity is caused by chlorpropamide, tolbutamide, alcohol, chlorpromazine, phenylbutazone, indomethacin, chloroquine, sulfonamides, ethambutol, chloramphenicol, isonex, clioquinol, quinine, streptomycin, and paraaminosalicylate. Yellow vision (xanthopsia) has been traced to the use of sulfonamides, streptomycin, methaqualone, barbiturates, chlorothiazide,... 

Systemically taken drugs that can induce photosensitivity are many. Of the drug groups given below, those most commonly reported are antimitotics dacarbazine, vinblastine antimicrobials demeclocycline, doxycycline, nalidixic acid, sulphonamides antipsychotics chlorpromazine, prochlorperazine cardiac arrhythmic amiodarone diuretics frusemide (furosemide), chlorothiazide, hydrochlorothiazide fibric acid derivatives, e.g. fenofibrate hypoglycaemic tolbutamide... 

In addition to chlorpromazine, phenylbutazone (an analgesic and antiinflammatory agent), sulfonamides (chemotherapeutic agents), chlorothiazide (a diuretic), thiouracil and methima-zole (antithyroid drugs), phenytoin (an anticonvulsant), pyribenzamine (an antihistaminic), and chloramphenicol... 

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