Chlorosulphonic acid purification

As an example of surface-modified latex particles via chemical reactions, there is the work of Imbert-Laurenceau et al. [130] PS particles functionalized by various amino acids were prepared in three steps by modifying chemically the surface of cross-linked PS particles. First, phenyl groups of PS were chlorosulphonated by reaction with an excess of monochlorosulfonic acid. Second, The PS-SO2CI was condensed with various amino acid methyl esters in order to obtain the different functionalized particles. Third, ester groups were hydrolyzed by successive washing of the particles with different aqueous solutions of NaOH. The final particles are able to strongly interact with antiviral antibodies. Due to these biospecific interactions, the functionalized particles are candidates to be used in vaccinal approach as virus-like polymers or as affinity matrix for the purification of antiviral antibodies. 

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