Isocyanate, chlorosulfonyl acid anhydride synthesis

This reaction sequence could be applied to the synthesis of the quassinoid analogs 15-0-P-octanoylglaucarubolone (98) and 15-0-P-3, 4 -dimethyl-2 -pentenoylglaucarubolone (99) (5). The latter, which has the bruceantin (53) ester side chain, was obtained by esterification of the hydroxylactone (95) with 3,4-dimethyl-2-pentenoic anhydride prepared by treatment of the corresponding acid with chlorosulfonyl isocyanate (35). 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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