Chlorophenoxy -1,2-propanediol

The a-glycerolether is prepared by condensing equimolar amounts of 4-chlorophenol (7.5.1.) and 2,3-epoxy-l-propanol (Glycidol) in the presence of a tertiary amine or a QAC as catalyst. Minimum inhibiton concentrations (source Kabara, 1984, e.g. 1250 mg/1 for Staphylococcus aureus, 2500 mg/1 for Pseudomonas aeruginosa and Aspergillus niger, 1250 mg for Candida albicans) present Chlorphenesin as a microbicide of moderate efficacy. Optimum pH range 4-6. Chlorphenesin is used as a preservative in cosmetic and pharmaceutical products. In the EEC Cosmetic Directive it is listed with a maximum permitted concentration of 0.3%. 

Because of the mechanism mentioned above the aldehydes with microbicidal effect are distinguished by broad spectra of effectiveness which also cover viri and spores. Since only few sporicides are found among microbicides, the sporicidal effect of aldehydes, particularly that of glutaric aldehyde is of special interest. Aldehydes are above all used for disinfecting purposes but also for preservation, then chiefly in the form of so-called aldehyde releasing compounds (3., 4., 5., 6.) 

Synonym/common name Chemical and physical properties Appearance 

Boiling point/range °C (101 kPa) Solidification point °C-118 Flash point °C Stability 

Chemical name Chemical formula Structural formula Molecular mass CAS-No. 

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Chlorphenesin Chlorphenesin, 3-(4-chlorophenoxy)-l,2-propanediol (15.3.14), is synthesized in the same manner as methocarbamol from 3-(4-chlorophenoxy)-1,2-propanediol [36-38]. 

C9H10O3 alpha-hydroxy-alpha-methylbenezeneacetic acid 515-30-0 32.41 1.1490 2 16867 C9H11CI03 3-(2-chlorophenoxy)-1,2-propanediol 5112-21-0 25.00 1.2162 2... 

Chlorophenoxy)-1,2-propanediol 2-(3-Chlorophenoxy)propanoicacid 2-Chloro-A/-phenylacetamide A/-(2-Chlorophenyl)acetamide... 

CAS 104-29-0 EINECS/ELINCS 203-192-6 Synonyms 3-(4-Chlorophenoxy)-1,2-propanediol p-Chlorophenyl o-glyceryl ether... 

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