Chloroformate 2-hydroxyethyl methacrylate

Acetic acid, acetone, acetonitrile, benzenerwater (1 1), chloroform, cyclohexanone, dichloroacetice acid, dichloromethane, N,N-dimethylacetamide, dimethyUormainide, dimethylsulfoxide, dioxane, ethanol, ethylene glycol monomethyl ether, formamide, formic acid, 2-hydroxyethyl methacrylate, isopropanol, methanol, 2-methoxyethanol, methyl ether ketone, morphloline, 2,2 -oxydiethanol, 1-penlanol, phenol, 1,2-propanediol, 1-propanol, propylene glycol, pyridine, letrahydrcrfuran, trielhyl phosphate, trifluoroacelic acid, trimelhyl phosphate, water ... 

The molecularly imprinted copolymer of 2-hydroxyethyl methacrylate (HEMA) and p-CyD-coupled HEMA was synthesized in chloroform to study its interaction with a pair of steroids cholesterol and testosterone [42]. The molecularly imprinted copolymer was found to absorb the print molecule several times better than an imprinted poly HEMA. Asanuma et al. [44] concluded that cholesterol binding by the HEMA polymer was not due to CyD inclusion because no inclusion of CyD to cholesterol can form in chloroform. Another strategy developed for imprinting using CyD elements is the vinyl CyD (Table 1 and 10.3(A)), which has been successfully applied for imprinting antibodies, oligo-peptides [45], and vancomycin [46[. 

Chloroformate 128 of 2-hydroxyethyl methacrylate 127, an intermediate for the synthesis of azo polymers useful for colon-specific drug deUvery, was prepared with triphosgene [68],... 

Essentially, the same basic protocol can be adapted for the preparation of non-covalently imprinted polymers. In this case, the cholesterol template monomer is replaced by the template to be imprinted and additional functional monomer (or monomers) is included in the polymerization mixture, at a predetermined molar ratio with respect to the template. Typical functional monomers might be chosen from amongst methacrylic acid, itaconic acid, vinylpyridine, dimethylaminoethyl methacrylate, acrylamide, hydroxyethyl methacylate, and many more. Typical solvents for non-covalent imprinting Include chloroform, THF, and acetonitrile. Templates are removed from non-covalently imprinted polymers by exhaustive washing with a suitable solvent. 

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