4-Chlorobenzoate dehalogenase

Chang KH, P-H Liang, W Beck, JD Scholten, D Dunaway-Mariano (1992) Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3. Biochemistry 31 5605-5610. 

Loftier F, R Muller, F Lingens (1991) Dehalogenation of 4-chlorobenzoate by 4-chlorobenzoate dehalogenase from Pseudomonas sp. CBS3 an ATP/coenzyme A dependent reaction. Biochem Biophys Res Commun 176 1106-1111. 

The dehalogenases (EC 3.8.1), a subclass of the hydrolases that act on the halide bonds in C-halide compounds, catalyze reactions of hydrolytic de-halogenation (Fig. 11.3,a), i.e., the replacement of a halide atom at a sp3 C-atom with a OH group. Exceptions include thyroxine deiodinase (EC 3.8.1.4), which catalyzes reductive deiodination on phenyl rings, and the bacterial 4-chlorobenzoate dehalogenase (EC 3.8.1.6), which forms 4-hydroxy-benzoate. 

Ni S, JK Fredrickson, L Xun (1995) Purification and characterization of a novel 3-chlorobenzoate-reductive dehalogenase from the cytoplasmic membrane of Desulfomonile tiedje DVCB-1. J Bacteriol Yll 5135-5139. 

Uotila JS, VH Kitunen, T Saastamoinen, T Coote, MM Hagblom, M Salkinoja-Salonen (1992) Characterization of aromatic dehalogenases of Mycobacterium fortuitum CG-2. J Bacteriol 174 5669-5675. van der Tweel WJJ, JB Kok, JAM de Bont (1987) Reductive dechlorination of 2,4-dichlorohenzoate to 4-chlorobenzoate and hydrolytic dehalogenation of 4-chloro-, 4-hromo-, and 4-iodohenzoate hyAcalig-enes denitrificans NTB-1. App/ Environ Microbiol 53 810-815. 

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