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5- Chloro-2-pyrazinecarbonitrile

Chloro-2-pyrazinecarbonitrile (130) gave 3-(3-terl-butylamino-2-hydrox-ypropoxy)-2-pyrazinecarbonitrile (131) [NaOCH2CH(OH)CH2NHBu( (made in situ), Me2NCHO, 70°C, 18 h 83%]594 or analogous substituted-phenoxy derivatives.1010... [Pg.163]

Amino-5-chloro-2-pyrazinecarbonitrile (132, R = Cl) gave 3-amino-5-methoxy-2-pyrazinecarbonitrile (132, R = OMe) (MeONa, MeOH, reflux,... [Pg.163]

Chloro-3-dimethylamino-6-nitropyrazine (184) gave 3-dimethylamino-6-nitro-2-pyrazinecarbonitrile (185) (CuCN, Me2NCIIO, 155°C, 18 h 62%).1313... [Pg.173]

Pyrazinecarboxylic acid underwent microbiological hydroxylation to give 3-oxo-3,4-dihydro- (36, R = H) (Alcaligenes eutrophus 70%), 5-oxo-4, 5-dihydro- (37) (.Pseudomonas acidovorans 96%), or 6-oxo-l,6-dihydro-2-pyrazinecarboxylic acid (38) (Alcaligenes faecalis 85%) 1091 Similar procedures afforded 5-chloro-3-oxo-3,4-dihydro-2-pyrazinecarboxylic acid (Alcaligenes eutrophus 50%) and 5-oxo-4,5-dihydro-2-pyrazinecarbonitrile (Agrobacterium sp 78%).1091... [Pg.195]

Amino-6-chloro-5-dimethylamino-2-pyrazinecarbonitrile (162) gave the unisolated carboximidate (163) (MeONa, MeOH, 20°C, 30 h), and thence 3-amino-6-chloro-/V-cyano-5-dimethylamino-2-pyrazinecarboxarnidine (164)... [Pg.323]

Pyrazinecarboxamide (177) gave 2-pyrazinecarbonitrile (178) (neat POCl3, 100°C, 90 min 85%) 509 5-oxo-4,5-dihydro-2-pyrazinecarboxamide gave 5-chloro-2-pyrazinecarbonitrile (179) (likewise 72% note additional conversion of the oxo into a chloro substutuent) 1681 and 6-amino-2-pyrazinecarbox-amide gave 6-amino-2-pyrazinecarbonitrile (POCl3, Me2NCHO, 50°C, 45 min 55%).38... [Pg.325]

Benzamido-2-pyrazinecarbonitrile 3-Benzamido-2-pyrazinecarboxamide 3-Benzoyl-5-bromo-2-pyrazinamine 2-Benzoyl-5-chloro-3-dimethylaminopyrazine 2-Benzoyl-3-chloropyrazine... [Pg.367]

Chloro-5,6-dimethyl-2-pyrazinamine 2-Chloro-3,5-dimethylpyrazine 2-Chloro-3,6-dimethylpyrazine 2-Chloro-5,6-dimethylpyrazine 5-Chloro-3,6-dimethyl-2-pyrazinecarbonitrile 5-Chloro-1,4-dimethyl-2,3 (17/, 47/)-... [Pg.386]

Chloro-5,6-diphenyl-2-pyrazinecarbohydrazide 5-Chloro-3,6-diphenyl-2-pyrazinecarbonitrile 3-Chloro-5,6-diphenyl-2-pyrazinecarboxamide 2-Chloro-3,5-diphenylpyrazine 1 -oxide 2-Chloro-3,6-diphenylpyrazine 1-oxide 2-Chloro-3,6-diphenylpyrazine 4-oxide 2-Chloro-5,6-diphenylpyrazine 1-oxide... [Pg.387]

Chloro-3-methoxy-2-pyrazinamine 2-Chloro-3-methoxypyrazine 2-Chloro-5-methoxypyrazine 2-Chloro-6-methoxypyrazine 6-Chloro-3-methoxy-2-pyrazinecarbonitrile 6-Chloro-3-methoxy-2-pyrazinecarboxamide 2-Chloro-6-methylamino-3,5-diphenylpyrazine 2-Chloro-3-methylaminopyrazine 6-Chloro-3-methylamino-2-pyrazinecarboxamide 5-Chloro-6-methylamino-2,3-... [Pg.391]

Dichloro-l-methyl-2(177)-pyrazinone (188, R = Cl) gave selectively 6-chloro-4-methyl-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile (188, R = CN) [CuCN, l-methyl-2-pyrrolidmone (solvent), 150°C, 6h 68%] ... [Pg.174]

See other pages where 5- Chloro-2-pyrazinecarbonitrile is mentioned: [Pg.155]    [Pg.334]    [Pg.394]    [Pg.155]    [Pg.334]    [Pg.394]    [Pg.147]    [Pg.155]    [Pg.174]    [Pg.238]    [Pg.334]    [Pg.357]    [Pg.357]    [Pg.357]    [Pg.358]    [Pg.358]    [Pg.358]    [Pg.358]    [Pg.358]    [Pg.359]    [Pg.359]    [Pg.359]    [Pg.392]    [Pg.393]    [Pg.394]    [Pg.394]    [Pg.394]    [Pg.409]    [Pg.147]    [Pg.155]    [Pg.195]    [Pg.334]    [Pg.359]    [Pg.386]   
See also in sourсe #XX -- [ Pg.147 , Pg.238 ]

See also in sourсe #XX -- [ Pg.147 , Pg.238 ]



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3 - 2-pyrazinecarbonitrile

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