5- Chloro-2-nitrophenol

Photooxidation of chlorobenzene in air containing nitric oxide in a Pyrex glass vessel and a quartz vessel gave 3-chloronitrobenzene, 2-chloro-6-nitrophenol, 2-chloro-4-nitrophenol, 4-chloro-2-nitro-phenol, 4-nitrophenol, 3-chloro-4-nitrophenol, 3-chloro-6-nitrophenol, and 3-chloro-2-nitrophenol (Kanno and Nojima, 1979). A carbon dioxide yield of 18.5% was achieved when chlorobenzene adsorbed on silica gel was irradiated with light (A. >290 nm) for 17 h. The sunlight irradiation of chlorobenzene (20 g) in a 100-mL borosilicate glass-stoppered Erlenmeyer flask for 28 d yielded 1,060 ppm monochlorobiphenyl (Uyeta et al., 1976). 

Chloronitrobenzene, see 4-Chloroaniline Chloronitromethane, see Chloropicrin Chloronitrophenol, see oChloronitrobenzene 2-Chloro-4-nitrophenol, see Chlorobenzene 2-Chloro-5-nitrophenol, see p-Chloronitrobenzene... 

Enzymic hydrolysis (25-40°C) at the heterosidic bond of the chromogenic substrates was followed either continuously (via formation of 2 -chloro,4 -nitrophenol) at pH 5.5 (O.D. 405 nm) or discontinuously (4-methylumbel-liferone fluorescence at pH 10, emission at A > 435, excitation at A366 nm). Reaction rates were calculated from the linear increase of O.D. (em = 9000 M-1cm-1) or fluorescence (standardization with 4-methylumbelliferone) versus time. Alternatively, an HPLC method was used to follow the formation of chromophoric reaction products, phenols and glycosides (1). Concentrations were calculated from peak heights after appropriate standardization. 

Lang M, Spiteller P, Hellwig V, Steglich W (2001) Stephanosporin, a "Traceless" Precursor of 2-Chloro-4-nitrophenol in the Gasteromycete Stephanospora caroticolor. Angew Chem Int Ed 40 1704... 

Chloromethylation, of caUxarenes 1403 2-Chloro-4-nitrophenol, gas-phase acidity of 312... 

Methylphenol in ethanolic solution treated with ferric nitrate nonahydrate (1 equiv.) and heated briefly for 30 sec. afforded an 83% yield of 4-methyl-2-nitrophenol. Under similar conditions 4-chlorophenol gave 4-chloro-2-nitrophenol (88%), 4-bromophenol gave 4-bromo-2-nitrophenol (64%) and 2-chlorophenol, a mixture of 2-chloro-4-nitrophenol (56%) and 2-chk>ro-6-nitrophenol (35%). Aluminium, chromium and copper(ll) nitrates were also used (ref.63). 

Methoxymethylation of 2-chloro-4-nitrophenol with paraformaldehyde and methanol occurred by the addition of concentrated sulphuric acid over 35mins. followed by reaction at 90-95°C during 4 hours. Dropwise treatment with methanol and continuation of refluxing for 2.5 hours resulted in a 93% yield of 2-chloro-6-methoxymethyl-4-nitrophenol (ref.74). 

Many AMY reference methods based on malto-oligosaccharides with auxiliary enzymes and/or indicator enzymes have been recommended. For the direct method, an artificial substrate, 2-chloro-4-nitrophenyl-a-D-maltotrioside (CNPT), is used for continuous monitoring of AMY activity. AMY hydrolyzes CNPT to maltotriose and 2-chloro-4-nitrophenol at high thiocyanate concentrations. The reaction is followed by monitoring the increase in absorbance due to the production of 2-chloro-4-nitro-phenoxide at 405 nm. A side reaction (reaction [X]) occurs with formation of glucose and 2-chloro-4-nitrophenyl-a-D-maltose, which accovmts for 8% of the product formed. 

Chloro-5-methylphenol 2-Chloro-5 -methylphenol 2-ChlorO 4-nitrophenol 6> Chlorophenol o-Chlorophenol o-Chlorophenol 6>-Chlorophenol m-Chlorophenol p-Chlorophenol / -Chlorophenol m-Cresol... 

Wubbels et al. reported the temperature dependent nucleophilic aromatic photosubstitution of the Sn2 Ar type. Irradiation of 2-chloro-4-nitroanisole (122) at 25 °C in aqueous NaOH gave three substitution products 2-methoxy-5-nitrophenol (123), 2-chloro-4-nitrophenol (124), and... 

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