2-chloro-, 7 -4-methylphenyl

It was identified to be 2-(2 -chloro-4 -methylphenyl)-amino-1,3-diazacyclopentene-(2) of the formula... 

Reaction of pyridines with dialkyl acetylenedicarboxylates in the presence of isocyanates in dry CH2C12 at room temperature produced 1-substituted 2-oxo-l,9a-dihydro-2/7-pyrido[l,2-tf]pyrimidine-3,4-dicarboxylates <2004TL1803>. One-pot, three-component synthesis of 1-substituted 2-oxo-l,llb-dihydro-2//-pyrimido[2,l- ]iso-quinoline-3,4-dicarboxylates and 4-(3-chloro-4-methylphenyl)-3-oxo-4,4a-dihydro-3/7-pyrimido[l,2-tf]quinoline-l,2-dicarboxylate was realized by the reaction of isoquinoline and quinoline with isocyanates and dialkyl acetylenedicarboxylates <2004S861>. Diastereomeric mixtures of l-tosyl-2-aryl-l,llb-dihydro-2/7-pyrimido[2,Ttf]isoquinoline-3,4-dicarboxylates were obtained from isoquinoline, iV-tosyl-benzaldehyde imines, and DMAD <2002OL3575>. 

Chloro-4-methylphenyl)benzotriazole (21) has thus been found to react with SchifTs base (22) to yield the 1,2,3-triarylpropane derivative... 

In the case of the reaction of 3-(3-chloro-4-methylphenyl)-6-chloro-1,2-benzisoxazole (96), an enhanced reactivity of the methyl groups as opposed to the analog lacking the chlorine atoms (90) has been observed. Thus, with Schiff s base (88) from 2-phenyl-6-formylbenzoxazole and o-chloroaniline, compound 96 yields the styryl derivative 97, whereas 90 fails to react under these conditions.54... 

As previously mentioned, the methyl group of 2-(p-tolyl)-s-triazolo-[l,5-a]pyridine is inert under the conditions of the Anil Synthesis. However, introduction of a chlorine atom in ortho position to this methyl group enables reaction to be carried out at 20°-30°C (Section II,E,3). Thus, for example, from 2-(3-chloro-4-methylphenyl)-j-triazolo[l,5-a]pyridine (19) and Schiff s base 171, the stilbene 172 is formed. In the case of 2-phenyl-7-methyl-j-triazolo[l,5-a]pyridine (173), however, reaction with 171 gives the styryl derivative 174, without additional activation of the methyl group.19... 

Of particular interest are cases in which substituents are present in ortho positions to the reacting methyl group. Apart from o-chloro-substituted derivatives, those with methoxy, carbonamido, sulfonamido, and phenylsulfonyl groups have been reported to undergo reaction.68 The 2-(3-chloro-4-methylphenyl)-5-methoxybenzotriazole (163) has been found to be particularly reactive, yielding, with SchifFs base 98, the stilbene 164.54... 

Chemical Name N-(2-Chloro-4-methylphenyl)-4,5-dihydro-lH-imidazol-2-amine nitrate... 

Synonym C 2242, Clortokem, Deltarol, Dicuran, Highuron, Higaluron, Tolurex Chemical Name 3-(3-chloro-p-tolyl)-1,1 -dimethylurea /V -(3-chloro-4-methylphenyl)-N,N-dimethylurea Uses herbicide to control pre- and post-emergent annual grasses and broadleaf weeds in winter cereals, particularly wheat and barley. 

An alternative to the use of silyl protection in RNA synthesis employs modified acetals such as l-(2-fluorophenyl)-4-methoxylpiperidin-4-yl (Fpmp) and l-(2-chloro-4-methylphenyl)-4-methoxylpiperidin-4-yl (Ctmp) groups. An improved synthesis of the enol ethers required to introduce these protecting groups has been devised. ... 

By contrast, (4-methylphenyl)[2-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]-bismuth 7/-(trifluoromethanesulfonyl)amide (5) is prepared in quantitative yield by the action of a 1 1 molar mixture of potassium tert-butoxide and trifluoromethanesulfonyl amide (TfNH2) on chloro(4-methylphenyl)[2-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]bismuthine in THF at room temperature [98OM1013]. In contrast to amide 4, the amide 5 is thermally stable and does not disproportionate when stood in a solution. 

The oxidative metabolites of chlortoluron were l-(3-chloro-4-methylphenyl)-3-formyl-3-methylurea, l-(3-chloro-4-methylphenyl)-3-formylurea, l-(3-chloro-4-methylphenyl)-3-methylurea and l-(3-chloro-4-methylphenyl)urea the metabolites of fluometuron l-(3-trifluorophenyl)-3-methylurea and l-(3-trifluoro-methylphenyl)urea and those of metobromuron l-(4-bromophenyl)-3-methyl-urea, l-(4-bromophenyl)urea and l-(4-bromophenyl)-3-hydroxy-3-methylurea. 

Solan Solan A- (3-chloro-4-methylphenyl) -2-methyl-pentanamide... 

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