Phenobarbital Chloramphenicol

Chloramphenicol Phenobarbital Phenytoin Primidone Risk of toxicity of the object drugs Inhibition of metabolism of the object drugs... 

Simultaneous caffeine, ceurbenicillin, ceftazidime, chloramphenicol, phenobarbital, phen-ytoin, salicylic acid, sulfamethodoxeizole, theophylline, ticarcillin... 

Azathioprine, chloramphenicol, colchicine, cyclophosphamide, cytarabine, 5-fluorodeoxyuridine, 5-fluorouracil, hydroxyurea, mercaptopurine, metformin, methotrexate, phenobarbital, phenytoin, primidone, proton pump inhibitors, pyrimethamine, sulfasalazine, and vinblastine... 

Ethanol increases phenobarbital metabolism, but valproic acid, cimeti-dine, and chloramphenicol inhibit its metabolism. 

Drugs that may affect tacrolimus include nephrotoxic agents (aminoglycosides, amphotericin B, cisplatin, cyclosporine), antifungals, bromocriptine, calcium channel blockers, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, methylprednisolone, metoclopramide, carbamazepine, phenobarbital, phenytoin, rifamycins, cisapride, chloramphenicol, metronidazole, nefazodone, omeprazole, protease inhibitors, macrolide antibiotics, fosphenytoin, and St. John s wort. 

Phenobarbital and Barbiturates, chloramphenicol, chlorpromazine, cortisol, coumarin anticoagulants,... 

Phenobarbital and other barbiturates1 Barbiturates, chloramphenicol, chlorpromazine, cortisol, coumarin anticoagulants, desmethylimipramine, digitoxin, doxorubicin, estradiol, phenylbutazone, phenytoin, quinine, testosterone... 

CHLORAMPHENICOL BARBITURATES 1 levels of these drugs, with risk of therapeutic failure Induction of hepatic metabolism 1. Avoid co-administration of telithromycin for up to 2 weeks after stopping phenobarbital 2. With the other drugs, monitor for 1 clinical efficacy, and t their dose as required... 

These are prepared by rapid solidification of the fused melt of two components that show complete liquid miscibility but negligible solid-solid solubility. Thermodynamically, such a system is an intimately blended physical mixture of its two crystalline components. Thus, the X-ray diffraction pattern of a eutectic constitutes an additive composite of the two components. A phase diagram of a two-component system is shown in Fig. 1. Examples of this type include phenacetin-phenobarbital, chloramphenicol-urea, griseofulvin-sucdnic acid, paracetamol-urea, and the dispersions of giiseofulvin and tolbutamide in polyethylene glycol-(PEG-2000).[ ... 

Phenobarbital can increase the rate of chloramphenicol metabolism and so lead to abnormally low serum chloramphenicol concentrations. In 17 children receiving chloramphenicol succinate alone, mean peak and trough serum concentrations were 25 and 13 pg/ml respectively. In six patients phenobarbital reduced these concentrations to 17 and 7.5 pg/ml respectively (76). 

Powell DA, Nahata MC, Durrell DC, Glazer JP, Hilty MD. Interactions among chloramphenicol, phenytoin, and phenobarbital in a pediatric patient. J Pediatr 1981 98(6) 1001-3. 

There are a large number of publications and papers in which the increase in absolute solubility of active substances by povidone has been tested and described. However, if the selection is restricted to the low-molecular types, this number becomes significantly smaller (Table 93). Naturally, a solubilization effect can also be expected of povidone K 12 and povidone K17, even if such an effect is reported in the literature only for the medium-molecular povidone (see Table 97), though the amounts of active substance complexed may differ according to the molecular weight of povidone (see Table 92). However, the influence of the molecular weight depends very much on the active substance with trimethoprim and chloramphenicol it is very large, while with phenobarbital it is small. 

The common examples are ester (aspirin), thiol ester (spirolactone), amide (chloramphenicol), sulfonamide (sulfapyrazine), imide (phenobarbital), lactam (methicillin), lactone (spiranolactone), and halogenated aliphatic (chlorambucil). 

Drug Interactions. Phenobarbital is a potent enzyme inducer and may increase the elimination of any drug metabolized by CYP450-or UGT-mediated metabolism. Valproic acid, phenytoin, felbamate, cimetidine, and chloramphenicol inhibit phenobarbital metabolism, necessitating a decrease in dose. Ethanol increases the metabolism of phenobarbital. ... 

Extracted amobarbital, barbital, caffeine, carbamazepine, chloramphenicol, ethosuximide, mephobarbital, methsuximide, pentobarbital, phenobarbital, phenytoin, primidone, secobarbital, theophylline, thiopental... 

Extracted metabolites, ethosxiximide, primidone, phenobarbital, phenytoin Simultaneous acetaminophen, N-acetylprocainamide, aspirin, ampicillin, caffeine, ce-phapirin, chloramphenicol, digoxin, disopyramide, hexobarbital, indomethacin, lidocaine, mephobarbital, methsuximide, nafcillin, pentobarbital, phenylethylmalonamide, procainamide, quinidine, salicylic acid, secobarbital, sulfamerazine, sulfamethazine, terbutaline, tetracycline, theobromine, theophylline... 

Extracted acetazolamide, ampicillin, bromazepam, caffeine, chloramphenicol, chlorothiazide, diazepam, droperidol, ethionamide, furosemide, isoniazid, methadone, penicillin G, phenobarbital, phenytoin, prazepam, propoxyphene, pyrazinamide, rifampin, trimepra-zine, trimethoprim... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

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